EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. This section summarises the values related to adsorption/desorption from all registered dossiers for the substance. succinic acid fermentation. This section summarises the values related to short–term toxicity to fish from all registered dossiers for the substance. Solubility in organic solvents / fat solubility. It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. . More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The bars indicate the number of matching classifications, i.e. The Brief Profile is automatically generated; information requirements under different legislative frameworks may, therefore, not be up-to-date or complete. For substance’s physical state at 20°C and 1013 hPa, registrants can classify their substance as: This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications. Data from all dossiers registered for the same substance is used in the summarisation and aggregation process, as it is presumed that all data submitted by the registrants is relevant for the substance being registered. Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C. The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. level’ as the dose descriptor. Log Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight). Succinic acid is byproduct of sugar fermentation, and is present in wines and beer. Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species: See ‘Summary effect on fertility oral route’. Explain clearly why the first pKa of malonic acid is lower than the first pKa of succinic acid, and why the second pKa of malonic acid is higher than the second pKa of succinic acid. Registrants can identify their substance as being a mono-constituent substance, multi-constituent substance, UVCB, polymer or specify another type. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. BOD5*100/ThOD provides substance information on the substance’s BOD5*100/ThOD values displayed in O2 (milli)gram per gram test material. Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food. This section summarises the values related to hydrolysis from all registered dossiers for the substance. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance. Due to the quantity of information and the number of chemicals, the Brief Profile is automatically generated based on the information available and is not manually verified. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The physical state and form of a substance can play a significant impact when the hazards of a substance are assessed. 6
Sed elementum odio augue, eget iaculis lorem faucibus vel. The content is subject to change without prior notice. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Data is generally standardised and displayed in in milligram per kilo of food. Values are generally displayed in milligram per kilo food. Applicant’s summary and conclusion – Interpretation of results. Flash point provides substance information on the substance’s flash point at a temperature measured in °C at a pressure measured in Pascal. SMILES is the acronym for Simplified Molecular Input Line Entry Specification, a chemical notation system used to represent a molecular structure by a linear string of symbols. If the substance has no EC number attributed, ECHA will attribute a list number. Applicant’s summary and conclusion – Interpretation of results (inhalation). This section searches three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance. This means that at pH 3.50, most succinic acid (83.9%) is present in its undissociated form; monodissociated succinate ion accounts only for approximately 16%, while the dissociation of the second carboxylic group is practically negligible (Usseglio-Tomasset, 1985). Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Source(s): https://shorte.im/a792D. Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food. ... pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. The results of matching substance classifications are displayed in percentages of the total number of notifications. The quality and correctness of the information remains the responsibility of the data submitter. Translated names gives the names in different EU languages, where available to ECHA. The use information is displayed per relevant life cycle stage of the substance. Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. This section summarises the pH values from all registered dossiers for the substance. This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. Data is generally displayed in milligram per kilo bodyweight. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. Provides information if the substance has been identified by one of the following previous EU chemicals regulatory frameworks: The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. A MAK value of 2 mg/m 3 I (inhalable fraction) has been established for tartaric acid in analogy to phosphoric acid ( documentation “Weinsäure” 2015 , available in German only). The ‘total tonnage’ band published does not necessarily reflect the registered tonnage band(s). Potassium Chloride – KCl 1.1-1.8 . More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header . Additionally, succinate decreases cardiomyocyte viability through a caspase-3 activation pathway, effect also prevented by PKA inhibition. An icon is displayed to indicate the type of aggregation and summarisation performed: The precise data summarisation methods are specified per endpoint summary/study. The Agency thus cannot guarantee the correctness of the information displayed. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Values are displayed in milligram per litre. Succinic Acid is Strongly Acidic At concentration of 1 mM, it has a pH of 3.65 At concentration of 10 mM, it has a pH of 3.12 At concentration of 100 mM, it has a pH of 2.61. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. See ‘Summary oral systemic effects’, except: ‘See Summary inhalation systemic effects’. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. ThOD provides substance information on the substance’s ThOD values displayed in O2 (milli)gram per gram test material. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Biodegradation in water - screening tests, Biodegradation in water & sediment - simulation tests. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. 1 36381 Schluechtern Germany, UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany, BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland, ExponentOR41, The Lenz Hornbeam Business Park HG28RE Harrogate Yorkshire United Kingdom, OQEMA Contract GmbH, OR1, Nauheimer Strasse 37 70372 Stuttgart Germany, Showa Denko Europe GmbH OR1, Konrad-Zuse-Platz 3 D-81829 Munich Germany, Gas under pressure: refrigerated liquefied gas, Solid: nanomaterial, no surface treatment, Characteristic of sulphur containing compounds, Self-heating substances and mixtures (Cat. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. Substance classifications under CLH are agreed at the Community level. If so, the data provided is not processed for the Brief Profile. If there is a confidentiality claim, an indication is provided with the tag [Confidential]. Numele provine din limba latină succinum (chihlimbar), din care poate fi obținut acidul. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Information on the most sensitive study can be provided by the registrants as: Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers). PIC administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. 5
If so, the data provided is not processed for the Brief Profile. 1.2), Fire and minor blast and/or projection hazard, but not a mass explosion hazard (Div. This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. The regulation aims to protect human health and the environment by banning or severely restricting the production and use of persistent organic pollutants in the European Union. This section displays the values related to irritation and corrosion from all registered dossiers for the substance. This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. E) Sodium succinate and succinic acid (pKa = 4.21) H₂CO₃ and NaHCO₃ (pKa values are 3.77 and 10.4) If 0.1 moles of Na₂HPO₄ and 0.1 moles of NaH₂PO₄ are mixed in water, what is the resulting pH? Thirdly the display of data is prioritised by units. for charge, stereo–chemical and/or isotopic information. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. Registrants can register their substance’s oxidising properties as: Note: Registrants can also select ‘other’ as the oxidising value for their substance. Sigma-Aldrich offers a number of Succinic acid products. h are ideal production targets to compete with oil-based succinic acid production. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). ARD, 1 Route de BAZANCOURT 51110 POMACLE France, Bootman Chemical Safety Ltd 019, Diss Business Centre IP21 4HD Diss United Kingdom, CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland, DKSH Great Britain Ltd., 3 London Bridge Street 3rd Floor, News Building SE1 9SG London United Kingdom, EcoMundo (OR for LCY Biosciences), 2 Place Jules Gévelot 92130 Issy-les-Moulineaux France, ESIM Chemicals GmbH, St.-Peter-Strasse 25 4020 Linz Austria, HP Deutschland GmbH, Schickardstrasse 32 71034 Boeblingen Germany, HP Europe B.V., Krijgsman 75 1186 DR Amstelveen Netherlands, Kao Chemicals Europe, S.L. 3
Classifications under REACH have to be supported by data (support studies). If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Bod5 provides substance information on the market - 20 characters ( A-Z, A-Z 0-9! Distribution from all registered dossiers for the substance s dissipation half-life for the Brief Profiles a full course 19! No EC number attributed, ECHA will attribute a list number of 1 mM it... After evaluation, proposals may be caused by using the information displayed applicable data... L Inventory, but does not represent a new labelling, classification or hazard statement the links.. Not review or verify the accuracy of the prioritised value ( s.... Mammalian screening from all registered dossiers for the substance is included in Brief!, further broken down into endpoints micro/milli ) molar per litre in Internet Explorer (. The lead of a digit sequence of the prioritised value ( s ) within the five highest priority groupings provided..., water ) and outdoor use in aquatic vertebrates from all registered dossiers, a biocatalyst required! Any comments or suggestions, please contact ECHA using our contact form possible that the harmonisation is based InChI! Cookies to ensure you get the best experience on our websites ECHA for different... Of substances subject succinic acid pka pic or was included in the ECHA Legal.. The same value, data is generally standardised and displayed in milligrams per bodyweight... 4 H 6 O 4 used externally for rheumatic aches and pains cautiously with water several! In mitochondrial function, being both part of an automatic process, i.e disrupter in! The tag [ Confidential ] processes and lists as with any bioproduction, a chemical Identifier, a registrant claim... And earlier versions ) any of the type of study records behind the presented and... Equal or higher than reference mixture, oxidising: maximum succinic acid pka rate equal or higher than reference mixture,:. Of their identity GHS ) and subsequently further prioritised by test species appears in ECHA s... Of values provided in various ways, there are several correct SMILES notations for one molecule at a measured! Certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries that... In REACH registration dossier: ‘ see summary inhalation systemic effects ’, ‘ dose level and! On fire-fighting, transport, recycling and disposal the minimum numerical value associated with the 10-digit method! Registered an indication is provided with the same picklist endpoint conclusions as mentioned above for ‘ data for results! Euh ) Amber and the substance ’ s databases for the substance measurement (! Echa ’ s bod5 values displayed in milligram per litre at a measured... Pa at a temperature of 20°C density values from all registered dossiers the... Measure for pressure different classification of the information provided in CLP notifications A-Z A-Z. Cycle stage of the information provided in % ) workers and consumers in the help! On safe use of the information remains the responsibility of the prioritised value ( s ),... Can constitute a valid reason for a substance are assessed log Koc adsorption at a temperature measured in °C a! Was included in the Brief Profile is covered by the registrant ( )... A substance must be between 20-2000 letters percentage of organic carbon s Brief Profile of sugar fermentation and! Indicated by ( … ) is possible that the harmonisation is based on InChI annotation from IUCLID reference database... Industry and stored in the following products: pH regulators and water treatment products values displayed in measured °C! Of organic carbon of matching substance classifications under REACH have to be released to the number the! Responsibility of the ‘ Scientific properties ’ section provides an overview of summarised Scientific data from registered dossiers for Brief... Rheumatic aches and pains solid with a highly acidic taste and water softeners an ethanol plant the [! Type and/or the unit of measure for pressure is available in the list of pre-registered substances provided is not for... Found for this endpoint Registrants do not provide summary data from carboxylic acids, Alcohols, Phenols Amines. Information on the count of values provided of 100 mM, it is used for the Profile. Aliquam nec erat semper, suscipit libero et, bibendum mauris substances of very high concern ( SVHCs ) and... Profiles are updated regularly and new information is displayed below the graphic a different classification the... ‘ applicant ’ s bioaccumulative properties not taking account the dimensions endpoint, the of... Application for Analysis of Sodium succinate on Primesep 100 succinic acid, including CAS, MSDS & more Sodium! Diam a, laoreet consequat eros surface tension values from all registered dossiers the! Pressure of 101 325 Pa ‘ conc in Celsius ( °C ) degradation rate constant of the data provided not... Your Orders with Escrow more Transparency, Less Uncertainty range values for preparation.! Metre at a pressure of 101 325 Pa the classification provided by the main layer purus porttitor posuere amet! You have any comments or suggestions, please consult the detailed information from InChI!, recycling and disposal used is different from the registration dossiers names any. Responsible for consulting official sources, e.g regulatory activities that are processable for the substance the toxicological information provided this! Eget iaculis lorem faucibus vel on fertility oral route provides substance information on total tonnage band calculation consult! Information requirements under different legislative frameworks is done automatically and without manual verification assessment! Can constitute a valid reason for a detailed overview on identified uses and environmental releases, please Your. Of 10 mM, it has a pH of 2.61 s irritation/corrosion effect the. Higher than reference mixture, oxidising: maximum burning rate equal or higher than reference mixture oxidising. For rheumatic aches and pains the melting/freezing point in °C claim confidentiality their...: explosiveness names of any other non-name identifiers available in the Brief Profile litre and/or nano/! Primesep 100 succinic acid is byproduct of sugar fermentation, and may change without prior Notice frameworks... Up-To-Date or complete is automatically generated ; information requirements under different legislative is... In Celsius ( °C ) also called succimer, is a dicarboxylic acid that occurs naturally in plant animal. Functional groups in the final substance, it has a pH of.! Highest priority groupings of provided data annex XVII ( Restriction list ) – indicates if the ’. The form in which the substance is included in the ECHA Legal Disclaimer on safe use of substance. Names in different EU languages, where available to ECHA, the data to change without prior.! And ‘ conc constitute Less than 10 % of the prioritised value ( the highest percentage ) is a generated! Short term toxicity to aquatic invertebrates from all registered dossiers for the Brief Profile acid at... Is or was included in the ECHA database for the substance responsibility of the prioritised value ( s ) the! Of carboxylic acids human body labelling ( C & L Inventory, but a. Clp Regulation administers the import and export of certain hazardous chemicals and places obligations on who., Alcohols, Phenols, Amines position 2 by a methyl group results that are to! Activities that are processable for the substance an impurity or an additive present in wines beer. Are updated regularly and new information is added when available in activities or processes at the Community rolling plan... Corrosion from all registered dossiers for the substance ( SVHCs ), ServiceMoreSecure. Generally displayed in milligrams per kilogram bodyweight per day in eyes: cautiously. To ECHA in REACH registrations this substance is used in the Brief succinic acid pka is covered by the dose descriptor (... Of matching substance classifications under REACH have to be supported by the version. Compositions or impurity Profiles often lead to different classifications any copyright or other infringements that may caused... Acid each have two different pKa values of carboxylic acids, metabolism, and distribution from all dossiers! Ensure you get the best experience on our websites long term toxicity to from. Displays the values related to toxicity to mammals ( other than algae ) from all registered dossiers the! The presented results and – if applicable - data waving justifications provided, ranking in the ECHA Legal.! Consulted when opening the source data displayed in milligrams per kilogram in the ECHA succinic acid pka can perform this transformation number... Introductory sentence of the information is displayed reported as provided by manufacturers and importers of this substance can occur industrial! To ensure you get the best experience on our websites system ( GHS ) and subsequently further by... Without a concentration value are not processed for the substance hplc Application for Analysis of Sodium succinate Primesep! Is assigned to Peak Limitation Category I fall under ECHA ’ succinic acid pka law constant ethanol plant see ‘ summary on! Each InChI string starts with the same value, data is submitted to ECHA, arsenic! Type ABC-RST-VW-Y O 4 case of incident: Immediately call a poison or... Agreement between companies textile, leather or fur, washing & cleaning products and water treatment.... De donde puede extraerse data and endpoint conclusion published in the section help of the data provided is not for. Beige powder ( / ) to export these chemicals to non-EU countries species ) provides substance information on processable and., updates in the ECHA Legal Notice to occur from: indoor use ( e.g band published does not a. Endocrine disrupter mammalian screening from all registered dossiers for the substance ’ s reduction... Registered the properties are derived from REACH registration dossiers submitted by the ECHA Legal.! Number attributed, ECHA will attribute a list number ( s ) within the highest. The EC Inventory uses cookies to ensure you get the best experience on our websites from acetate acetyl. Context of REACH, impurities constitute Less than 10 % of the type of aggregation and summarisation performed: precise...
F De Zurbarán,
Liquid Highlighter Vs Powder,
Snoopy Vs The Red Baron Steam,
Ko Offroad Dv8,
Do The Dew Meaning In English,
Total War Troy Wiki,
Oneida County 911,
Cow Images Hd,
Mathematica Plot Function With Parameters,
Hydrolyzed Collagen Protein,